Pathophysiology and Management of Hypercoagulation in Infectious Diseases

Abstract Numerous systemic infections may have hypercoagulation as one of the complications, which range from asymptomatic presentation elevation biochemical markers coagulation such that fibrin and thrombin generation, to a much severe, symptomatic, life-threatening, disseminated intravascular (DIC), results in formation thrombi microvasculature various organs. This phenomenon contributes increase morbidity mortality infectious diseases. The current review discusses mechanisms during tissue factor activation, endothelial cell inhibition physiological anticoagulant pathways, fibrinolysis inhibition. also pathophysiological changes system its management recent pandemic COVID-19. article role parenteral oral anticoagulants provides clinical data on used hospitalization extended prophylaxis for venous thromboembolism infections. Methodology Because this is published literature no humans or animals were involved, ethical committee approval was not required patient consent required.